In reality, the mono-pile foundation system of OWT (Offshore Wind Turbine) can be damaged due to uncertainties and variations in both ocean environmental loadings and/or soil resistance around the foundation. In other words, the uncertainty parameters directly influence the safety, the performance and the structural behavior of a structure. In this study, a laterally loaded mono-pile foundation for OWT structure is considered to examine the degree of influence of uncertainties in the pile-soil system of the structure by an accurate and practical reliability assessment approach.