Experiments were conducted in order to assess the healing effect of bee venom (BV) cream on full-thickness skin wounds in rabbits. BV cream was compared with silver sulfadiazine (SS) as a topical medicament against a control on experimentally created full-thickness wounds. Two wounds measuring 2 × 2 cm were created bilaterally (four wounds/rabbit) on the dorsolateral aspect of the trunk of seven New Zealand white rabbits. Wound treatments were evenly distributed on four sites, using a Latin square design. The contact layer of wounds was treated with physiological saline (control), SS cream, and BV cream over a period of 28 days. Assessment of wound healing was based on scab hardness, wound exudates, wound area, unepithelialized granulation tissue, and histopathological findings. Topical application of BV and SS creams to wounds resulted in reduced inflammation, debridement of necrotic tissue, and promoted granulation and epithelialization. Wound healing was faster, with statistical significance in BV and SS treatments, compared to the control (P<0.05). Treatment with BV evoked an anti-inflammation effect in a rabbit model. BV cream produced a wound healing effect similar to that of commercially available SS cream. Anti-inflammation effect as a topical treatment with BV cream appears to be better than that with SS cream. These results suggest that topical application of BV cream may be an alternative treatment for full-thickness skin wounds.

방사선장해 극복을 위한 조직공학실험에서는 다양한 실험방법이 존재한다. 그중에서도 방사선 장해모델을 구현함에 있어서 쥐는 가장 많이 사용되는 실험동물이다. 이번 실험에서는 쥐 피부를 벗긴 후 일정한 두께로 만든 후에 피부 두께에 따른 방사선량을 측정하였다. 또한 쥐의 피부 두께에 따른 방사선 흡수선량을 유추해 날수 있는 수식을 도식화 하였다. 결론적으로 이러한 수식을 적용한다면 방사선장해극복을 위한 조직공학 연구에서 사용하는 다양한 지지체삽입시에 지지체가 받을 수 있는 방사선량의 정도를 유추해 낼 수 있으며 이것을 통하여 쥐 피부두께 피하에 관한 체내 (in-vitro)실험모델 구현 시 방사선량의 정보를 제공하고자 한다. 따라서 이번 연구의 결과를 기반으로 사용한다면 방사선이 노출된 쥐의 피하조직 체내 (in-vitro) 조직공학 실험에서 효과적으로 사용 될 수 있을 것이다.

The oriental ore minerals, which mainly consisted of talc, actinolite, sericite, and halloysite were developed, and then used to examine the healing effect on the skin wound in rats. Full-thickness square wounds were formed on the backs of rats after the hairs on the dorsal surface were shaved. The ore minerals were applied to examine the healing effect from day 0 to 15 after wounding. Notable wound healings in terms of congestion around the wound, wound contraction and epithelialization were found in ore mineral-treated groups. Moreover, microscopic results revealed the formation of epithelial layer, hair follicles and progressive angiogenesis in ore mineral-treated groups, while complete epithelial layer could not be found in the control. These results suggest that ore minerals from Korean indigenous ores may have wound healing effect on the skin injury in rats.