Cordyceps bassiana (asexual stage Beauveriabassiana) is a widely distributed entomopathogenic fungus that infects hundreds of various insects. It produces a number of secondary metabolites, including insect toxins beauvericin and bassianolide and pigment tenellin. In the present study, members of NRPS and PKS-NRPS hybrid genes were predicted from whole genome sequences of eighteen different fungal species belonging to five families of Hypocreales (Cordycipitaceae, Clavicipitaceae, Ophiocordycipitaceae, Hypocreaceae and Nectriaceae) using antiSMASH ver. 1.2.2. Phylogeny using all predicted adenylation (A) domains was drawn in order to identify potential orthologous genes of beauvericin synthetase (BbBEAS) and bassianolide synthetase (BbBSLS) in Hypocreales. The orthologs were examined to understand the evolution of beauvericin and bassianolide synthetase genes. Phylogenetic tree shows grouping of A1 and A2 domains of BbBEAS, BbBSLS and enniatin synthetases in two separate clades indicating the origin of genes from fusion of two distantly related modules. Species phylogeny of C. bassiana and its allies is congruent with gene trees of BbBEAS and BbBSLS, suggesting that the gene fusion event predates the species divergence. In the inferred phylogeny, A1 domain of BbBEAS showed highest similarity with that of BbBSLS, followed by those of Fusarium equiseti enniatin synthetase and Xylariasp. bassianolide synthetase. Syntenic analysis of beauvericin gene clusters of C. bassiana and closely related species represents that C. militaris lost the BbBEAS gene in evolution. Synteny of bassianolide gene clusters shows the loss of NRPS genes encoding BbBSLS in B. pseudobassiana, Isaria tenuipes, I. farinosa and C. pruinosa. BbBEAS and 2-ketoisovalerate reductase (kivr) genes are found conserved in beauvericin and enniatin synthesizing gene clusters.
The relationship between mission and imperialism has been one of the central themes which recur throughout missiology, in particular, mission history. In the case of the Korean Church, this theme also has particular significance for church history in that it was related to the origin of the Korean Church, especially the Korean Protestant Church. This study attempts to examine this theme, with special reference to the World Missionary Conference in Edinburgh, 1910. It is because, first, the Korean Church was established in the context of imperialism; second, in Korea did arise an irregular case of the relationship between mission and imperialism, namely, western mission versus non-western imperialism rathallthan normal one, namely, western mission versus western imperialism; and third, the abovementioned Edinburgh Conference was held at the peak period of imperialism, from the late nineteenth century to the early twentieth century.
Since the last year was the centennial of the Edinburgh Conference, the Conference was almost thoroughly investigated. In this context, it may also be well worth exploring the Conference from the perspective of the relationship between mission and imperialism. In particular, this study tries to grasp the reality of the Korean Church at the period under consideration, through unearthing archival material, that is, the draft reports to the Commissions of the Edinburgh Conference, which have rarely been utilized in the hitherto studies.
In conclusion, this study makes it clear that the western mission, including the western mission working in the non-western imperial context, in the pre-World War Ⅱ period was largely under the influence of the ideology of imperialism, although mission could not totally identify with imperialism. It is against this backdrop that arises a question of whether the end of imperialism means the end of mission. This is why the post-colonial period exacts a new paradigm of mission.