대한구강악안면병리학회지 제46권 제2호 (p.25-34)

카테콜-O-메틸트랜스퍼아제 유전자(rs4680)와 섬유근육통 사이에 연관성: 최신 메타분석

Association between Catechol-O-Methyltransferase Gene (rs4680) and Fibromyalgia: Updated Meta-Analysis
키워드 :
Catechol-O-Methyltransferase Gene(rs4680),Fibromyalgia

목차

Ⅰ. INTRODUCTION
Ⅱ. MATERIALS and METHODS
   1. Search Strategy
   2. Inclusion Criteria and Data Extraction
   3. Statistical analysis
Ⅲ. RESULTS
   1. Characteristics of Eligible Studies
   2. Heterogeneity and Model Selection
   3. No Publication Bias between Eligible Studies
   4. No Association between COMT rs4680 (G>A,Val-158-Met) Polymorphism andFibromyalgia
Ⅳ. DISCUSSION
Ⅴ. CONCLUSION
REFERENCES

초록

The association between the COMT rs4680 (G>A, Val-158-Met) polymorphism and the risk of fibromyalgia has been investigated in previous studies, but the results are controversial. Therefore, a meta-analysis has been performed to confirm the association between COMT rs4680 (G>A, Val-158-Met) polymorphism and the risk of fibromyalgia in this study. Our study includes eleven case-control studies with 2,909 individuals comprised of 1,365 fibromyalgia patients and 1,544 control subjects. The regression analysis was performed using the random effects model or the fixed effects model and OR with the corresponding 95 % CI was calculated for the allele, recessive, dominant, over-dominant, co-dominant 1, and co-dominant 2 model. No statistical significant associations were observed between COMT rs4680 (G>A, Val-158-Met) polymorphism and risk of fibromyalgia in allele model (P-value = 1.00), recessive model (P-value = 1.00), dominant model (P-value = 0.54), co-dominant 1 model (P-value = 1.00) and co-dominant 2 model (P-value = 1.00). In conclusion, our meta-analysis showed that the COMT rs4680(G>A, Val-158-Met) polymorphism might not be genetic risk factor for the fibromyalgia.