This study analyzed the prevalence and determinants of work-related musculoskeletal disorders (WMSDs) using domestic statistical data from 2007 to 2024. Over the past 18 years, the number of WMSD cases approved for industrial accident compensation increased by 110.6%, accounting for 60.3% of all occupational diseases, confirming it is a serious social issue. In this empirical study, we utilized crossanalysis and Pearson's Chi-squared test to examine the relationship between WMSD types and worker characteristics (gender, age) and workplace characteristics (industry, size). The analysis revealed a statistically significant difference in WMSD types based on the worker's gender, age, industry, and workplace size, confirming all hypotheses. Men had a higher proportion of diseases from "tasks imposing excessive physical burden," while women had a higher rate of "carpal tunnel syndrome". The incidence of disorders from physically demanding tasks was also higher with increasing age, in physically intensive sectors like manufacturing, construction, and mining, and in larger workplaces. These findings underscore the critical need for future WMSD prevention policies to be tailored by comprehensively considering both worker characteristics and the specific work environment. The results of this study provide valuable foundational data for establishing targeted and effective occupational health and safety policies, ultimately contributing to the reduction of industrial accidents and improving the well-being of workers.