Background : The human patch test is a method used to evaluate potential skin irritation after contact with a cosmetic materials. Pectin lyase-modified red ginseng extract (GS-E3D) is a newly developed ginsenoside Rd-enriched ginseng extract. This study was designed to investigate the skin safety of GS-E3D in human patch test.
Methods and Results : Thirty two female volunteers were tested with GS-E3D. GS-E3D (20 ㎕) was applied to occlusive patch test devices and was then applied onto the back of subject with normal skin for 24 hours. Cutaneous irritation responses were evaluated and graded according to criterion of International Contact Dermatitis Research Group (ICDRG) at 30 min, 24 hours, and 48 hours after removing of GS-E3D patch. The average age of subjects was 47.3 ± 9.3 years. Skin reactivity calculated from irritation score in GS-E3D treated group was 0.51 and skin irritation score of no application group was 0, respectively. Skin irritancy was no response in both GS-E3D treated group and no application group. From above data, GS-E3D was identified as a non-irritant according to ICDRG guideline that skin irritation score of ‘0.00 - 0.75’ is a non-irritant.
Conclusion : These results indicate that GS-E3D can be useful as a safe cometic ingredient.

• 표미경((재)금산국제인삼약초연구소) | Mi Kyung Pyo Corresponding author
• 이경희((재)금산국제인삼약초연구소) | Gyeong Hee Lee
• 김진성((재)금산국제인삼약초연구소) | Jin Seong Kim
• 조윤호((재)금산국제인삼약초연구소) | Yun Ho Jo
• 이유진((재)금산국제인삼약초연구소) | You Jin Lee
• 정다유((재)금산국제인삼약초연구소) | Dayu Jung
• 유대석((재)금산국제인삼약초연구소) | Dae Seok Yoo
• 김원용((재)금산국제인삼약초연구소) | Won Yong Kim
• 차선우((재)금산국제인삼약초연구소) | Seon Woo Cha
• 박기용((주)세화피앤씨) | Ki Young Park
• 이기무((주)세화피앤씨) | Ki Moo Lee