Recently, airborne fungi as indoor air pollutant have attention due to its health related problems such as asthma, rhinitis, sinusitis, atopy, pneumonia, building syndrome and etc.. However, it is considered that current laws and policies in Korea are not efficient to deal with these problems. Our research investigated influential factors and species distribution on the basis of previous research related to airborne fungi issue conduced in Korea by applying meta analysis technique. We selected 15 articles containing variables affecting fungi population such as outdoor air characteristics, temperature, location, and ventilation to evaluate significant factors. It was confirmed that airborne fungi level has partial correlation to those factors despite of limited sample size. It is required that the consistent and systematic research effort should be extended to characterize health effect caused by these fungi as well as to control them efficiently.

This study analyzed the major change of revised Construction Technology Promotion Act in the field of safety management. In order to increase the execution of the system of construction safety management, Construction Technology Promotion Act was revised at the end of 2018. The key issues were founded in the system of safety management plan, regular safety inspection by external professional organization, and irregular safety inspection by clients. By revised law, the role and responsibility of construction clients was enforced and the clients were recognized as leading participants in construction safety management.

Background : The human patch test is a method used to evaluate potential skin irritation after contact with a cosmetic materials. Pectin lyase-modified red ginseng extract (GS-E3D) is a newly developed ginsenoside Rd-enriched ginseng extract. This study was designed to investigate the skin safety of GS-E3D in human patch test. Methods and Results : Thirty two female volunteers were tested with GS-E3D. GS-E3D (20 ㎕) was applied to occlusive patch test devices and was then applied onto the back of subject with normal skin for 24 hours. Cutaneous irritation responses were evaluated and graded according to criterion of International Contact Dermatitis Research Group (ICDRG) at 30 min, 24 hours, and 48 hours after removing of GS-E3D patch. The average age of subjects was 47.3 ± 9.3 years. Skin reactivity calculated from irritation score in GS-E3D treated group was 0.51 and skin irritation score of no application group was 0, respectively. Skin irritancy was no response in both GS-E3D treated group and no application group. From above data, GS-E3D was identified as a non-irritant according to ICDRG guideline that skin irritation score of ‘0.00 - 0.75’ is a non-irritant. Conclusion : These results indicate that GS-E3D can be useful as a safe cometic ingredient.

Background : Pectin lyase-modified red ginseng extract (GS-E3D) is a newly developed ginsenoside Rd-enriched ginseng extract. This study was designed to investigate the acute oral and dermal toxicity of GS-E3D in rat. Methods and Results : The acute oral toxic effects of GS-E3D in female SD rats were examined at dosages of 300 ㎎/㎏ and 2,000 ㎎/㎏. In acute dermal toxicity study, 500, 1,000 and 2,000 ㎎/㎏ of GS-E3D were applied onto the shaved skin of male and female SD rats. The weights of rats were recorded at 0, 1, 3, 7, and 14 days and clinical observation were checked once a day for a period of 14 days. All rats were scarified on 14th day and complete gross examination was conducted to detect any gross change of organs after necropsy. GS-E3D did not produce orally or dermally treatment-related clinical signs of toxicity or mortality in all rats during the 14-day observation period. The oral and dermal LD50 values of GS-E3D were over 2,000 ㎎/㎏ in rat. The oral and dermal administration of GS-E3D revealed no significant change in body weight and gross pathology examination compared to control group. Conclusion : These results indicate that GS-E3D can be used as a food and cosmetic materials without critically adverse effect.

This study is proposed to establishment of collaborative environment utilizing BIM-based digital model for cable bridge oversea market entry. It is important to utilization of digital model based framework as such analysis interface, pre-construction technology, data sharing system by design company, general contractor, maintenance agent and government office.