We investigated the relationship between the TiO2 photocatalytic decomposition of bisphenol A in water and biological toxicity to zebrafish (Danio rerio) during 1～28 weeks post development stage. The bisphenol A in water was completely degraded by the TiO2 photocatalysis in 50 hours. After the photocatalysis, no toxic effects on the morphogenesis of the zebrafish were observed during the development, growth, and maturate stages. Catalase activity of control group was not different from 1～5 week post fertilized group. However, toxic effect on the catalase activity of adult stage(28 weeks) decreased 50% than control group.

The effects of bisphenol A on the catalase activities in the development stage of zebrafish were investigated. In this study, the catalase activities for zebrafish fries exposed to bisphenol A of 1×10-10 g/ℓ during 1 week, 2 week, and 4 week post-hatching were examined. Also, the changes of organs weight and the catalase activities for adult zebrafishes exposed to bisphenol A during 3 weeks were investigated. Catalase activities for zebrafish fries exposed to bisphenol A of 1×10-10 g/ℓ during 1 week post-hatching were significantly lower, compared to the control. Somewhat, for zebrafish fries exposed to bisphenol A during 4 week post-hatching, catalase activities were significantly increased. For adult zebrafishes, the effects of bisphenol A were higher for female than male. Specially, catalase activities were significantly increased in the ovary of zebrafishes exposed to bisphenol A during 3 weeks. The ovary weight were increased for zebrafishes exposed to bisphenol A during 3 weeks. Catalase activities were increased in the intestine of female exposed to bisphenol A during 3 weeks. Catalase activities were increased in testis exposed to bisphenol A during 3 weeks but there was no significance. In conclusion, the damages of an endocrine disrupter were higher in the earlier development stage compared with adult. The damages were higher for female exposed to an endocrine disrupter compared with male.