Purpose: This study aimed to understand the meanings and nature of the lived experience of participating in integrated simulation practice of standardized patients with complex problems. Methods: The hermeneutic phenomenological human science approach developed by van Manen was adopted in-depth interviews and observations were conducted with 6 standardized patients’ and recorded with their consent. The data were collected over two months, from March 1, to April 30, 2016. The statements were analyzed and revealed five essential themes of the standardized patients with complex problems. Results: The essential themes of outcomes consisted of <Conflict between the virtual and real world>, <Inadequate and surprise nursing interventions>, <Limitations of the standardized patient role>, <Identified with the standardized patient>, and <Rewarding patient role>. Conclusion: The standardized patients who participated in this study had difficulty in carrying out the role of the patient, and they said that the nursing students felt that they were rewarding because they were helpful.