Purpose: This study aims to investigate the effect of a simulation-based patient safety performance improvement education program on caregivers’ knowledge, attitude, and performance toward safety. Methods: This study adopted a quasi-experimental design that applied before-and-after designs for the test and control groups. It was configured focusing on “infectious disease,” “fires,” “falls,” and “drug abuse.” Results: There was a significant difference in knowledge and patient safety performance between the experimental group and the control group. However, there was no significant difference in attitudes toward safety. Conclusion: The results of this study showed that the simulation-based patient safety performance improvement education program is effective in improving patient safety performance. Therefore, it is necessary to continuously apply and evaluate the simulation-based patient safety performance training program to enable caregivers to develop professional prevention and management capabilities within elderly care facilities