Shandong Province, as a big province of cultural resources, has abundant cultural resources and the rapid development of cultural industries. At the same time, the contradiction between the protection and development of cultural resources is increasingly prominent, threatening the sustainable use of cultural resources. Based on this, the article systematically analyzes the classification, characteristics, and utilization status of cultural resources in Shandong Province from the perspective of sustainable development. According to the clustering characteristics of regional characteristic cultural resources in Shandong Province, it proposes the construction of five major cultural industrial clusters and the realization of culture. The concept of the development of sustainable use of resources provides a new way to promote the effective protection and rational development of cultural resources in Shandong Province and promote the transformation and upgrading of cultural industries.