Based on the findings on similarities and differences in the Korean and Vietnamese cultural features, and the social surveys conducted as part of the project ”Compiling, Publishing and Disseminating the Handbook of Korean-Vietnamese Behavior” by South Korean Studies Center, University of Social Sciences and Humanities, Vietnam National University - Ho Chi Minh City (USSH-VNU-HCM) with the support of the Academy of Korean Studies (AKS) from September to October 2016,the paper covers the three points: First, analyzing similarities that create a special interaction effect between the two cultures. They are ones underlying the spectacular development of the Korea-Vietnam relations during the past time. Among them are similarities in the humanity and tolerance with a distinctive feature of “respect for affection”, playing the most important role;second, analyzing cultural collisions caused by distinctive features in the structures of the two countries’ traditional cultures. They include those of the South Korean culture namely strong hiarachy, high respect of routines, and self-esteem of mono-culture and those of the Vietnamese culture namely strongvillage democracy, low respect of formalities, resistance to imposed culture; and simultaneously analyzing the gaps in the modernity of the Vietnamese workers' culture compared to the requirements of modern production in Korean enterprises so as to point out that they are reasons for the increase of conflicts in Korean enterprises’ operation process in Vietnam; and third, suggesting, based on the analysis, some cultural solutions to increase harmony and reduce conflicts, supporting a sustainable development of the Korea-Vietnam cooperation in Korean enterprises in Vietnam.