A female English bulldog was gave birth two neonates by cesarean section on the sixty one days after mating, but both neonates were died soon after birth. The bodies of neonates were diagnosed using radiography, ultrasonography, computed tomography and necropsy immediately after death. Both neonates had caudal regression syndrome, butterfly vertebra, hydrocephalus, umbilical hernia, cleft palate and bow-legged hind-limb. At necropsy, neonates had mild fetal anasarca, cleft lip and the skull was remained non-union. At thoracic cavity, only three ribs and thoracic spines were existed and patent ductus arteriosus was found. At abnormal cavity, the renal ectopia was found with abnormal morphology. In the present case, those English bulldog neonates with multiple congenital malformation syndromes seriously suffered vertebral column anomalies and that may induced by neural tube defects in during embryonic period. To prevent congenital malformation occurring in English bulldog, further in depth studies are needed for the breed specific genetic diversity and for the reason of behind genetic abnormality in these breed.

Purpose: This study aimed to develop an algorithm-based simulation scenario for emergency measures for a high-risk newborn presenting apnea. Methods: A methodological study design was used to develop the algorithm-based simulation scenario. Expert evaluation was used to establish the developed algorithm’s content validity. Results: The simulation scenario was developed using several steps of algorithm development based on the Neonatal Resuscitation Program (NRP). The content validity was established. Based on the expert evaluation results, an eight-frame algorithm was selected for the final simulation scenario. The scenario courseware was composed of six major components: pre-learning activity simulation orientation, simulation operation, SBAR-format recording, watching the video-clip of their performance for self-evaluation and debriefing. After simulation, student’s clinical performance and communication skill were evaluated with the developed instrument. Conclusion: Considering that nursing students have limited access to high-risk newborns during their clinical experience and that newborns presenting apnea are common in the neonatal intensive care unit, the algorithm-based simulation scenario developed in this study can provide students with the opportunity to practice alternative emergency measures for high-risk newborns.

Liver cancer represents a major health problem with steadily increasing incidence rates. Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third most common cause of cancer-related death. This study was conducted in order to investigate the gross findings following treatment with diethylnitrosamine (DEN) in mice. Sixteen male and female mice (B6C3F₁), initially 20 days of age, received intraparietal injection (20 mg/kg three times for a period of two weeks, IP) or were given drinking water (DW) containing 50 ppm DEN; all mice were sacrificed at the 80^th week of experiments. Hepatocellular adenoma (HCA) and HCC were induced in B6C3F₁), mice by administration of DEN. The numbers of HCA and HCC were 7.4±1.72 (IP) and 7.2±0.86 (DW) in male mice. However, no significant difference was observed between the DW and IP groups. The numbers of HCA and HCC were 0.67±0.33 (IP) and 2.0±0.63 (DW) in female mice. This study showed a tendency for high incidences of liver tumor with long-term exposure of newborn animals by drinking water.

본 연구는 돼지 골수에서 존재하는 조혈 줄기 세포 및 전구 세포를 이용해 이종 동물 모델인 태아 마우스 복강 생체 이식을 통하여 돼지 조혈 세포의 이종 조혈 조직에서의 증식과 분화 특성을 규명하였다. 선천성 면역 부전 마우스인 NOD/SCID 마우스 태아 조혈 환경에 돼지 골수 유래 조혈 줄기 세포 및 전구 세포를 이식하고, 이식 후 5주령에 마우스 조혈기관에서의 돼지 조혈 세포의 증식과 분화 특성을 돼지 특이적 항체 면역 염색으로 유세포 분석을 실시한 결과, 마우스 조혈 조직인 골수, 흉선, 간장, 비장 및 림파절에서 돼지 조혈 세포의 분화 및 증식이 관찰되었다. 특히 돼지의 T 면역세포가 골수계 세포에 비해서 높은 chimerism이 관찰되어 태생 초기의 NOD/SCID 조혈 환경에 의한 특이적 T 면역세포의 증식에 적합한 조혈 환경을 제공하고 있다는 사실이 밝혀졌다. 본 마우스 신생 NOSD/SCID 복강 이식 동물 모델을 이용해 돼지 T 면역세포의 분화 발달 연구 및 이종 장기 이식 기전 연구에 좋은 모델로서 활용이 기대된다.

This study was conducted to determine the main effects of the parity and farrowing season on gestation length and newborn pigs on the basis of the data obtained from 234 litters of Landrace breeds raised at an integrated swine farm in Kyunggy province from January 1991 to December 1992. The results obtained are summarized as follows ; 1. The average gestation length was 115.37 days, and 114.64 days of 8th parity and over was shorter than those of other parities. 2. The averages of litter size and litter size alive per sow were 9.91 and 9.50 heads. The litter size horn at 1st parity was smaller than at other parities, and the litter size in spring was larger than in summer, autumn or winter. 3. The averages of birth weight per litter and pig were 13.53 kg and 1.37 kg. The effect of farrowing season for each litter weight(p<0.01) and pig weight(p<0.05) at birth was significantly higher in spring than other seasons. 4. Incidence of malformation and stillbirth at birth was 4. 10%, and it at 8th parity and over showed the highest rate(7.50%).

T. S. 엘리엇의 초기 시 ｢불멸의 속삭임｣과 윌리엄 워즈워드의 ｢어린 시절 회상으로 부터의 불멸의 암시｣에서 서로 공통적인 요소가 발견된 다. 엘리엇은 형이상학파 시인들의 남겨놓은 불멸의 유산을 전통으로 받아들임으로써 불멸성을 설명하였고 워즈워드는 어린 시절 기억을 통하여 천국에서 막 태어난 신성한 자취를 신성한 불멸성이라고 찬양하였다. 본 논문은 낭만주의적 불멸성을 어린아이가 바로 태어난 이후에 지니고 있는 불멸성을 “생후 불멸성”이라고 모더니즘적 불멸성은 17세기 시인들의 죽음의 흔적을 통해 그리고 그 흔적들과의 대화를 통해서 얻어내는 불멸성을 “사후 불멸성”이라고 지칭하고 그 차이를 살펴보고자 한다. 그리고 결국, 왜 엘리엇은 전통과 불멸성을 동일시했고 왜 워즈워 드는 어린 시절에서 신성을 찾으려했는지를 각각의 시대의 사상을 통해 증명해 보려고 한다.