This study aims to compare and analyze a willow tree (Salix Koreensis andersson) extract’s antioxidant and antiinflammatory activity by investigating its: total polyphenol, flavonoid content, SOD-like activity, DPPH vitality. the willow tree was induced with LPS to determine its active anti-inflammatory effects. as a result, the willow methanol extract showed a higher total polyphenol and flavonoid content than those of willow distilled water extract, but the willow distilled water extract showed a higher SOD than that of willow methanol extract. in its DPPH scavenging ability, the willow methanol extract’s antioxidant activity was higher than that of the willow distilled water extract. the willow extract’s measurements such as the production of NO, inflammatory cytokine (TNF-α, IL-6 measurement) were significantly reduced as its concentration level went down. according to the research outcomes, when induced, he will extract’s macrophage produces mediator-like substances such as NO and inflammatory cytokine that can be used to alleviate the inflammatory response. therefore, the willow tree proved to be a useful raw plant material for the products designed to combat inflammatory activities due to its natural antioxidant and anti-inflammatory response substances such as NO and cytokine.