KOREASCHOLAR

The study was conducted to identify the anti-inflammatory and anti-cancer effects in sprouts of mouse-eyed bean (Rhynchosia nulubilis), ginseng (Panax ginseng), perilla (Perilla frutescens), broccoli (Brassica oleracea var. italica), and lettuce (Lactuca sativa) grown with organic germanium concentrate. Western blot analysis was performed to assess the antiinflammatory activity of the extract. All extracts exhibited noticeable anti-oxidant activity, indicating a significant correlation between the germanium content and anti-oxidant activity (p<0.05). In particular, rat-eyed bean sprouts with the highest germanium content showed significant anti-inflammatory activity (p<0.05) by significantly inhibiting the expression of the inflammatory complexes, NLRP3, cytokines IL-1β and caspase-1. Ginseng and broccoli sprouts showed strong anti-cancer properties and had high anti-oxidant effects (p<0.001). Germanium-concentrated water allows the mass production of agricultural products containing high concentrations of organic germanium. Agricultural produce grown with germanium concentrate add organic germanium to various physiological active ingredients, increasing the anti-oxidant and anti-cancer effects. These results strongly suggest that agricultural products containing high germanium concentrations can be used as novel health supplements to improve health.

Abstract
I. 서 론
II. 연구 내용 및 방법
    1. 게르마늄 농축수 제작
    2. 게르마늄 농축수에 의한 농산물 재배 및 시료 준비
    3. 게르마늄 함량 분석
    4. 세포 배양
    5. MTT assay
    6. 항산화 활성 분석
    7. Western blot analysis
    8. 통계처리
III. 결과 및 고찰
    1. 게르마늄 함유 농산물의 항산화 효과
    2. 전립선 암세포주(PC-3)에서 게르마늄 함유 농산물의 세포증식 억제 효과
    3. 게르마늄 함유 농산물의 항염효과
IV. 요약 및 결론
References

• 이명선(청주대학교 바이오메디컬학과) | Myeong-Seon Lee (Department of Biomedical Science, Cheongju University) Corresponding author