Oenothera biennis Seed Extract Attenuates N-(carboxymethyl)lysine-High Fat Diet-Induced Hepatic and Metabolic Dysfunction in Mice
- 언어ENG
- URLhttps://db.koreascholar.com/Article/Detail/446640
pp.220-226
Advanced glycation end products (AGEs) are closely associated with obesity mediated metabolic dysfunction, including hepatic injury, dyslipidemia, and glucose intolerance. Oenothera biennis seed (OBS) has been reported to have antioxidant and anti-inflammatory properties, but the protective effects against AGE-induced metabolic disorder remain unclear. In this study, a CML-high fat diet (HFCML) mouse model was used to evaluate the effects of the OBS extract. OBS supplementation significantly attenuated kidney hypertrophy induced by HFCML diet. The serum alanine aminotransferase and aspartate aminotransferase levels were elevated in the HFCML group, and were reduced significantly by OBS administration. OBS administration also improved lipid metabolism by lowering triglycerides and low-density lipoprotein cholesterol. Furthermore, OBS administration enhanced glucose tolerance. Overall, OBS extract mitigates HFCML-induced metabolic dysfunction by improving liver function, normalizing lipid profiles, and enhancing glucose tolerance, highlighting its potential as a functional food ingredient for the prevention of AGE-associated metabolic diseases such as non-alcoholic fatty liver disease and insulin resistance.
I. Introduction
II. Materials and Methods
1. Preparation of Oenothera biennis seed (OBS) extract
2. Animal model
3. Oral glucose tolerance test (OGTT)
4. Biochemical analysis
5. Statistical Analysis
III. Results and Discussion
1. Effects of OBS extract on body weight in HFCML dietmice
2. Effects of OBS extract on serum liver biomarkers inHFCML diet mice
3. Effects of OBS extract on serum lipid profile in HFCMLdiet mice
4. Effects of OBS extract on oral glucose tolerance inHFCML diet mice
IV. Summary and Conclusion
Author biography
Acknowledgment
Conflict of Interest
References