이 연구는 제2형 당뇨 모델 동물인 Goto-Kakizaki(GK) 흰쥐를 사용하여 운동과 셀레늄 투여가 미토콘드리아 생성과 기능 향상을 조절하는 전사 인자의 발현 변화와 현상학적으로 당뇨의 증상 개선을 유도할 수 있는지를 구명하기 위해 실시하였다. 실험동물은 52주령된 GK 수컷 흰쥐로 24 m/min, 30 min/day, 5 days/week, 총 6주간 트레드밀 런닝을 실시하였다. Sodium selenite(5 umol/kg)는 selenium

The objective of this study is to identify the effects of endurance exercise and selenium on mitochondrial transcription factor in old Goto-Kakizaki (GK) rats. In this experiments, endurance exercise were treadmill-run at 24 m/min, 30 min/day, 5 days/week, 6 weeks and 5 umol/kg of sodium selenite was injected intraperitoneally. In exercise group, selenium group, and combination group, the mitohondrial biogenesis-related genes, including PGC-, NRF-1, and Tfam expression level were significantly increased compared to control group. Consistent with the increased biogenesis-related genes, the cytochrome C in the treated groups, which was the indicator of mitochondrial content, was significantly increased compared to control group. Especially, combination of exercise and selenium may be effective in the increase of mitochondrial biogenesis, activity and insulin sensitivity. Therefore, exercise and selenium treatment is likely to promote diabeticmitochondrial malfunction and then improve diabetes.

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