In this paper, we propose the escape game Loony considering natural interaction. For user's immersion, the proposed game is designed similar to the real world such as a security card key, its card reader, coin, and a vending machine. In order for the user to easily understand the situation in the virtual environment, the proposed game provides enough information in game user interface. For easy operation, the proposed game reacts based on simple input method: mouse and just few keys on keyboard. For the purpose of verifying the effects of the interaction between the proposed game and the user, we compare the proposed game with two previous escape games based on the observational evaluation and the questionnaire evaluation. The evaluation results show that the proposed game is better than the previous games on the operation feeling and the situational awareness of the users.