Antioxidant capacity and acetylcholinesterase (AChE) inhibitory activity of the aqueous methanolic extract of Rhus javanica were investigated in vitro. The antioxidant properties was measured by radical scavenging assays using DPPH and ABTS+ radicals. The AChE inhibitory efficacy of R. javanica was tested by Ellman's assay and the total phenolic content was determined using a spectrophotometric method. All tested samples showed a dose-dependent AChE inhibitory and radical scavenging activities. In particularly, ethyl acetate (EtOAc)-soluble portion from the methanolic extract of R. javanica showed significantly higher inhibitory activity than other organic solvent soluble-portions in an AChE and radical scavenging assay systems. These results suggest that R. javanica may be possess potential benefits which might be useful in development of antioxidant and anti-alzheimer's disease ingredient.

• 배종섭(경북대학교 약학과, 약학연구소) | Jong-Sup Bae
• 이현식(경북대학교 자연과학대학 생명과학부) | Hyun-Shik Lee
• 이하영(경북대학교 약학과, 약학연구소) | Ha Yeong Lee
• 유병혁(영남대학교 식품공학과) | Byung-Hyuk Yoo
• 김태완(안동대학교 식품생명공학과) | Taewan Kim
• 김용한(대구한의대학교 한약재약리학과) | Yong Han Kim
• 김태훈(대구한의대학교 한약재약리학과) | Tae Hoon Kim Corresponding author