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Inhibitory Effect of Angelica keiskei Extract in an Atopic Dermatitis Animal Model

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  • URLhttps://db.koreascholar.com/Article/Detail/241356
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한국식품저장유통학회 (The Korean Society of Food Preservation)
초록

The purpose of this study was to evaluate the anti-atopic-dermatitis effect of Angelica keiskei extract using a DNFB-induced animal model of atopic-dermatitis symptoms. A. keiskei was prepared via extraction with DW, 50% ethanol, and 100% ethanol in addition to fresh juice. All the extracts reduced the thickness levels of the ears and ear epidermis against swelling by DNFB inducement, especially in the aqueous-extract-treated group. The mRNA expressions of matrix metalloproteinases (MMPs), however, were not observed, which may indicate that Angelica keiskei extract alleviates the atopic-dermatitis symptoms in an MMP-independent manner. Finally, the level of the inflammatory cytokine IL-4 was inhibited only in the juice-treated group, although the IL-13 level was inhibited in the juice-, 50%-ethanol-extract-, and 100%-ethanol-extract-treated groups in a dose-dependent manner, and was not inhibited in the aqueous-extract-treated group. Taken together, these results suggest that Angelica keiskei extract has an inhibitory effect on atopic dermatitis, and may be a useful biomaterial for the development of cosmeceuticals.

저자
  • 김민아(경북대학교 식품공학부) | Min-A Kim
  • 손형우(경북대학교 식품공학부) | Hyeong-U Son
  • 남동윤(경북대학교 식품공학부) | Dong-Yoon Nam
  • 차용수(경북대학교 식품공학부) | Yong-Su Cha
  • 신용규((주)바이온 부설연구소) | Yong-Kyu Shin
  • 최용희(경북대학교 식품공학부, 경북대학교 식품생물산업연구소) | Yong-Hee Choi
  • 이상한(경북대학교 식품공학부, 경북대학교 식품생물산업연구소) | Sang-Han Lee Corresponding author