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김치로부터 분리한 Leuconostoc citreum GR1의 마우스에 대한 급성독성 KCI 등재 SCOPUS

Acute Toxicity of Leuconostoc Citreum GR1 Isolated from Kimchi in Mice

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  • URLhttps://db.koreascholar.com/Article/Detail/241394
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한국식품저장유통학회 (The Korean Society of Food Preservation)
초록

The present study was carried out to investigate the in vivo single-dose acute toxicity of Leuconostoc citreum GR1 (Leuc. citreum GR1), a lactic acid bacteria isolated from kimchi, in ICR male and female mice. The test article was orally administered once to both sexes of mice. The mortalities, clinical findings, autopsy findings, and body weight changes were monitored daily for two weeks. The male and female mice were gavaged with Leuc. kimchi GR1 of four doses (625, 1,250. 2,500 and 5,000 mg/kg). The oral LD50 of Leuc. citreum GR1 was considered higher than 5,000 mg/kg. No significant changes in the general conditions, body weights, clinical signs and presence of gross lesions were observed in both sexes of mice to whom Leuc. citreum GR1 was administered orally. The results indicated that the 5,000 mg/kg dose of Leuc. citreum GR1 showed no adverse effect.

저자
  • 이환(조선대학교 식품영양학과) | Hwan Lee
  • 차선숙(조선대학교 식품영양학과) | Seon-Suk Cha
  • 이명렬(조선대학교 식품영양학과) | Myung-Yul Lee
  • 장해춘(조선대학교 식품영양학과) | Hae-Choon Chang
  • 이재준(조선대학교 식품영양학과) | Jae-Joon Lee Corresponding author