We could not find researches for relationship between safety performance and business performance in comparison with other research areas. Then in this paper we suggest the hypotheses which can systematically explain the relationship between safety performance and business performance and analyze the effects of safety performance on business performance through regression analysis. In order to develop the regression model between safety performance and business performance, the previous studies both for environmental management and for quality management had been reviewed. We obtained the result that the number of the injured persons in occupational accident and the number of lost work day because of the accident which are selected as measurement for safety performance had an effect on business performance through empirical analysis both for large 43 enterprises and for small and medium 30 enterprises. Also we had found that the control variables selectively 3had an effect on business performance. Finally, we concluded that the safety performance had an effect on business performance both for large enterprise and for small and medium enterprise.