In this paper, effects of information sharing in multi-level supply chain management have been studied through simulation. The simulation model consists of a manufacturing company as a center, three suppliers, two logistic centers, and three different retail supply lines of each logistics centers. The mathematical model and the simulation were developed when real-time information sharing occurs and does not occur in supply chain under the assumption that each company applies (s, S) inventory policies. In addition, this paper analyzed the effects of the change of variables related to total costs, which compose of total ordering cost, total transportation cost, total carrying cost and shortage cost that are caused by the change of demand of three different patterns with the way of information sharing.