This paper reviewed the relationship among job characteristics, psychological stress response, and accidents, and the mediating effect of psychological stress response between job characteristics and accidents. Based on the responses from 176 employees, the results of multiple regression analysis appeared as follow; 1) autonomy, importance and feedback effect negatively on psychological stress response. 2) psychological stress response effects positively on accident frequency. 3) psychological stress response mediates fully between autonomy and accident. 4) psychological stress response mediates partly between feedback and accident.