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In-vitro Anti-inflammatory Activity of Rubus coreanus Miq. on Nitric Oxide, Interferon-γ, Cycloxygenase-2, and Tumor Necrosis Factor-α Production in the Macrophage like Cell Line RAW 264.7 Activated by Lipopolysccharide
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- URLhttps://db.koreascholar.com/Article/Detail/255200
pp.324-328
To search for immunoactive natural products exerting anti-inflammatory activity, we have evaluated the effects of the ethanol extracts of Rubus coreanus Miq. (ERC) on lipopolysaccharide-induced nitric oxide (NO), tumor necrosis factor-α (TNF-α), and Interferon-γ (IFN-γ) production by RAW 264.7 macrophage cell line. Our data indicate that this extract is a potent inhibitor of NO production and it also significantly decreased IFN-γ and TNF-α production. Consistent with these results, the protein level of inducible Nitric Oxide Synthase (iNOS) and cyclooxygenase-2 (COX-2) was inhibited by ethanol extracts of ERC in a dose-dependent manner. These results suggest that ERC may exert anti-inflammatory and analgesic effects possibly by suppressing the inducible NO synthase and COX-2 expressions.
