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신남산 유도체 VI. Cinnamenylisophorone 유도체에 대한 Thiourea의 친핵성 첨가반응메카니즘과 그 반응속도론적 연구 KCI 등재
Cinnamic Acid Derivatives VI, The Kinetics and Mechanism of the Nucleophilic Addition of Thiourea to Cinnamenylisophorone Derivatives
pp.65-72
The kinetics of the addition of thiourea to cinnamenylisophorone derivatives(X : H, p-Br, p-CH3 m-CH3, p-OCH3) was investigated using ultraviolet spectrophotometry in 20%(v/v) dioxane-H2O at 25℃. A rate equation which can be applied over wide pH range(pH 1.0~13.0) was obtained. In order to investigate the substituent effects of cinnamenylisophorone derivatives. Hammett constant was plotted. As the result, the rate of uncleophilic addition of thiourea to cinnamenylisophorone derivatives was facilitated by electron donating group. It was found that addition of neutral thiourea which was not dissociated at the pH 1.0~9.0 was proceeded, the reaction was proceeded by addition of dissociated anion of thiourea above the pH 10.0. On the basis of this kinetic study, the reaction mechanism of nucleophilic addition of thiourea was investigated.
