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고상법에 의한 Dermorphin 유사체의 합성과 생물학적 활성에 관한 연구 KCI 등재
Synthesis of Dermorphin Analogues by the Solid Phase Method and Biological Activity
한국응용과학기술학회지
(The Korean Society of Applied Science and Technology)
Vol.19 No.4 (2002.12)
pp.281-290
pp.281-290
한국응용과학기술학회(구 한국유화학회)
(The Korean Society of Applied Science and Technology (KSAST))
초록
Dermorphin is a hepta peptide(H-Tyr-DAla-Phe-Gly-Tyr-Pro-Ser-NH2)with exceptionally potent and long-lasting peripheral and central activity. Dermorphin analogues, dermorphionyl(DMP)-Lys-NH2 and DMP-Lys-Lys-NH2 have been prepared in order to examine the effect of opiod activity. Dermorphin analogues were synthesized by the solid phase method. The crude peptide was purified by gel filter on a Sephadex LH-20, characterized with HPLC and amino acid analyzer. Analgesic potency was estimated by writhing syndrome method and Randall-Selitto method. As a result, dermorphin analogues have lower potency than that of morphine.
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