The benzophenone derivatives(4-CH3O-4'-NO2 and 3,4'-di-NO2) are synthesized by the Fridel-Craft acylation and the nitration method. Electrochemical redox potentials of the benzophenone derivatives (4-CH3O, H, 3-Cl, 3-NO2, 4-NO2, 4-CH3O-4'-NO2, 3,4'-di-NO2) are measured by using cyclic voltammometry. In the relationship of summing Hammett value and redox potential, we find a proportional constant(σ) that shows a good relation with an electrochemical property and a reactivity of the benzophenone derivatives. The benzophenone substituted with the electron donating groups(4-OCH3 and 4-OCH3-4'-NO2) are higher the energy in the LUMO level, then increasing a band-gap energy(Eg), their Egs are obtained as a 3.94 eV and 3.59 eV, respectively.

Dermorphin is a hepta peptide(H-Tyr-DAla-Phe-Gly-Tyr-Pro-Ser-NH2)with exceptionally potent and long-lasting peripheral and central activity. Dermorphin analogues, dermorphionyl(DMP)-Lys-NH2 and DMP-Lys-Lys-NH2 have been prepared in order to examine the effect of opiod activity. Dermorphin analogues were synthesized by the solid phase method. The crude peptide was purified by gel filter on a Sephadex LH-20, characterized with HPLC and amino acid analyzer. Analgesic potency was estimated by writhing syndrome method and Randall-Selitto method. As a result, dermorphin analogues have lower potency than that of morphine.

2-phenyl-N-methyl-1,3-thiazolium perchlorate(PTP)derivatives were synthesized via addition and substitution reactions. PTP was hydrolyzed under aqueous hydrochloride. The structures of the compounds were conformed by N.M.R.,I.R., and elemental analysis.