In T-mixer crystallization, supersaturation is generated by mixing of another solvent or non-solvent in order to reduce the solubility of the compound. Also, T-mixer is a type of continuous crystallization. In order to induce micro-mixing, two solutions were mixed rapidly by T-mixer, which formed high supersaturation. As the results, mean size of HMX crystals decreased with increasing de-supersaturation rate (Rs). Eventually, HMX particles ranging from 0.5 to 5μm can be obtained by T-mixer crystallization. Mixing efficiency in T-mixer increased with increasing Rs values. In T-mixer crystallization without surfactants, homogeneous nucleation was formed when S and Rs was over 54 and 1.6×103/sec. In T-mixer crystallization with surfactants, homogeneous nucleation was formed when S and Rs was over 26 and 7.4/sec.