Brucella spp. are facultative intracellular pathogens that have the ability to survive and multiply in professional and nonprofessional phagocytes and cause abortion in domestic animals and undulant fever in humans. Brucella species can survive in a variety of cells, including macrophages and their virulence and chronic infections are thought to be due to their ability to avoid the killing mechanisms within macrophages. Inhibition of phagosome-lysosome fusion has been proposed as a mechanism for intracellular survival of Brucella in professional and nonprofessional phagocytes. Toll-like receptors (TLRs) are part of a skillful system for detection of invasion by microbial pathogens. Recognition of microbial components by TLRs triggers signaling pathways that promote expression of genes and regulate innate immune responses. Recent studies for the interaction between TLRs-Brucella have indicated the importance of control of Brucella infection. Here, we review selected aspects of TLRs-Brucella interaction, which may be helpful to understanding the mechanism of Brucella pathogenesis.

• Dae Geun Kim(College of Veterinary Medicine, Gyeongsang National University)
• Hannah Leah Tadeja Simborio(College of Veterinary Medicine, Gyeongsang National University)
• Alisha Wehdnesday Bernardo Reyes(College of Veterinary Medicine, Gyeongsang National University)
• Wongi Min(College of Veterinary Medicine, Gyeongsang National University)
• Hu Jang Lee(College of Veterinary Medicine, Gyeongsang National University)
• Jin Ju Lee(Animal and Plant Quarantine Agency)
• Suk Kim(College of Veterinary Medicine, Gyeongsang National University, Institute of Agriculture and Life Science, Gyeongsang National University) Corresponding author