The several functions of manufactured the gypsum incorporating oyster shell powder coated by submicro-silver solutionand carrried out the tests for the adsorption of formaldehyde and antibiotic actions. Several environmentally- friendlyarchitectural materials, clay and flyash were tested for the comparison of the adsorption efficiency. The mortar by solidifiedand dried was exposed in the small chamber for the 180min with 4000µg/m3 of the initial concentration of formaldehydeand observed high removal efficiency which result was not any difference in adsorption performance of other tested materials.The microbial flora analysis of oyster mortar coated by submicro-silver solution and the similarity test were performed andobserved that the densities of Aeromonas sp. Enterococcus sp., and Micrococcus sp. were decreased and the densities ofStaphylococcus sp., Escherichia sp., Bacillus sp., were taphylococcus sp, Escherichia sp., and Bacillus sp. were increased.