Gastrointestinal tuberculosis is a commonly presenting ileocecal disease. Appendiceal tuberculosis results from secondary to either ileocecal tuberculosis, or tuberculosis at other sites of the abdomen. "Isolated" form of tuberculosis affecting appendix only, without evidence of disease elsewhere, is very rare. We report on two cases of isolated appendiceal tuberculosis initially presenting as acute appendicitis. Each case was proven as tuberculosis by acid fast bacilli or caseous necrosis in pathology. Colonoscopy and abdominal computed tomography showed neither intestinal nor intra-abdominal disease.