This study was carried out to investigate the effects of Hericium erinaceus extract on the Anti- inflammatory and Anti-bacterial. To investigate in vitro Anti-bacterial activity assay, hot water extracts of Hericium erinaceus carried out using a broth micro-dillution method following the Clinical and Laboratory Standards Institute guidlines(Citron and Hecht, 2003; Jorgensen and Turnidge, 2003). In the next experiment, to investigate anti-inflammatory test, the RAW 264.7 macrophage, cells was cultured using DMEM including the 10% FBS. Hericium erinaceus extract has the effects of anti-inflammation and, which may be due to its inhibitory potential on the macrophage activation. Furthermore, Hericium erinaceus extract has the anti-bacterial effects through the inhibitory Propionibacterium acnes(P. acnes) and periodontopathic bacteria, Porphyromonas gingivalis , Fusobacterium nucleatum and Tannerella forsythia. The above results suggest that Hericium erinaceus hot water extract could be applicable for improvement of several inflammatory disease.

• Mi-hyang Jang(Future Agricultural Research Institute, Jeollanamdo Agricultural Research and Extension Service, Naju 520-715, Korea)
• Tae-Heong Kang( School of Biological Sciences and Technology, Jeonnam National University, Gwangju, 500-757, Korea) | Tae-Heong Kang
• Duk-Su Choi( Future Agricultural Research Institute, Jeollanamdo Agricultural Research and Extension Service, Naju 520-715, Korea) | Duk-Su Choi
• Kyung-Ju Jeong( Future Agricultural Research Institute, Jeollanamdo Agricultural Research and Extension Service, Naju 520-715, Korea) | Kyung-Ju Jeong
• Guk-Pil Bang( Future Agricultural Research Institute, Jeollanamdo Agricultural Research and Extension Service, Naju 520-715, Korea) | Guk-Pil Bang
• Ki-choul Jeong( School of Biological Sciences and Technology, Jeonnam National University, Gwangju, 500-757, Korea) | Ki-choul Jeong
• Kyung-Ju Choi( Future Agricultural Research Institute, Jeollanamdo Agricultural Research and Extension Service, Naju 520-715, Korea) | Kyung-Ju Choi