Mushrooms including Mycoleptodonoides aitchisonii are used as foods and employed as folk remedies for diabetes and inflammatroy diseases. This study analyzed anti-diabetic effects of Mycoleptodonoides aitchisonii, which grows in some areas such as Gangwon-do and Jeju-do in Korea, as insulin-derived phosphorylation. When 100 ng/ml of IL-6, inflammatory cytokine was given to SK-hep1, HepG2, Akt phosphorylation by insulin was found to be remarkably reduced. In addition, metformin, Antidiabetics serving as positive control in liver was used. Mycoleptodonoides aitchisonii used for analyzing anti-diabetic effects in this test didn’t give a great impact on the decrease in Akt phosphorylation by IL-6 at high concentration. However, fruit body in Mycoleptodonoides aitchisonii inhibited the decrease in Akt phosphorylation by IL-6 according to the concentration. At the highest concentration 100㎍/ml, it had an effect of increasing Akt phosphorylation to 77%, which was decreased by 50% compared to the insulin treated group by IL-6. Therefore, Mycoleptodonoides aitchisonii fruit body used in this test activated Akt phosphorylation inhibited by IL-6 and showed a possibility of significant anti-diabetic effects compared to positive control(metformin).

• Oh Deuk-Sil(Jeonnam Forest Resource Research Institute, Naju 520-833, Korea)
• Kim Hyun-Suk( Jeonnam Forest Resource Research Institute, Naju 520-833, Korea) | Kim Hyun-Suk
• Kim Sang-Kyum( College of pharmacy and RCTCP, ChungnamNational University, Daejeon, 305-353, Korea) | Kim Sang-Kyum
• Wi An-Jin( Jeonnam Forest Resource Research Institute, Naju 520-833, Korea) | Wi An-Jin
• Park Whoa-Shig( Jeonnam Forest Resource Research Institute, Naju 520-833, Korea) | Park Whoa-Shig
• Shin Hyun-Jae( College of engineering, Chosun University, Gwangju, 501-759, Korea) | Shin Hyun-Jae