This study was carried out to investigate neuronal protective activity of fruiting body of Hericium erinaceum. In order to search the effective active compound against amyloid beta peptide-induced oxidative stress on neuronal cells, rat pheochromocytoma cells (PC12), Extracts of Hericium erinaceum were screened and evaluated using both the 2’,7’-dichlorofluorescin diacetate assay (DCF-DA), and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. According to above assays, Solvent partitions of extracts were selected for further purification and isolation of anti-Alzheimer’s disease compound as it exerted the highest protective effects against hydrogen peroxide (H2O2)-induced oxidative stress.

• Hyung-Jun Noh(Development of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumseong, Chungbuk, 369-873)
• Kang-Hyo Lee( Development of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumseong, Chungbuk, 369-873) | Kang-Hyo Lee
• Chang-Sung Jhune( Development of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumseong, Chungbuk, 369-873) | Chang-Sung Jhune
• Jae-Han Cho( Development of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumseong, Chungbuk, 369-873) | Jae-Han Cho
• Gi-Ho Sung( Development of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumseong, Chungbuk, 369-873) | Gi-Ho Sung
• Kab-Yeul Jang( Development of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumseong, Chungbuk, 369-873) | Kab-Yeul Jang
• Sun-Young Um( Development of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumseong, Chungbuk, 369-873) | Sun-Young Um
• Geum-Soog Kim( Development of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumseong, Chungbuk, 369-873) | Geum-Soog Kim
• Seung-Eun Lee( Development of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumseong, Chungbuk, 369-873) | Seung-Eun Lee
• Young-Ok Kim( Development of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumseong, Chungbuk, 369-873) | Young-Ok Kim