Trunk injection of nematicides was applied to prevent pine wilt disease (PWD). Although the trunk injection of nematicides was effective to PWD prevention, it was not effective to a vector, Monochamus alternatus. Thus, This study was investigated for the insecticidal activity and the effect of oviposition deterrence by injecting to pine trees with systemic insecticides such as Acetamiprid SC 10%, Imidacloprid DC (20%), and Thiamethoxam DC (15%). As a results, mortality of M. alternatus adults was 100% at 56 days after trunk injection. Percentage of M. alternatus adults moved to a young black pine tree by trunk injection of Imidacloprid DC (20%) and Thiamethoxam DC (15%) in screen cage (4.0×2.0×2.5m) was 76.7% and 70.0%, respectively. But the mortality of M. alternatus adults showed 100%. Percentage of M. alternatus adults moved to the treated and untreated young black pine trees by trunk injection of Acetamiprid SC (10%) in screen cage (4.0×2.0×2.5m) were 25.9% and 49.5% at 1st day and 3rd day after treatment, respectively. Percentage of M. alternatus adults oviposited to treated pine logs at 3month after trunk injection of liquid mixture of Acetamiprid SC (10%) and Emamectin benzoate EC (2.15%) in screen cage (72×72×100㎝) was 25%. But, untreated pine logs was 100%