Laser welding is high power density welding process which is higher speed and productivity, lower thermal deformation. Recently, zinc coated sheet metal is used for many industrial due to the high corrosion resistance. This study explained that it used DOE(Design of experiment) and mathematical statistics method to optimize the conditions of high power laser welding process for zinc coated sheet metal. Finally, optimal condition for laser welding is selected for zinc coated sheet metal by alteration of welding joint width and gap.