This paper describes the results of experimental testing of GFRP composite beam strengthened reinforced concrete (RC) slabs with two symmetrical openings. The aim of this study is to investigate the most effective strengthening method using GFRP composite beams in slabs with openings for enhancing the load-carrying capacity and stiffness. Test results showed that the strengthened slabs seem to increase the load-carrying capacity by 29%, 21% and 12% over that of the control specimen for diagonal, parallel and surround strengthening, respectively. Furthermore, test results showed that diagonal-strengthened system is one of the most effective methods for RC slab with openings in terms of load-carrying capacity, stiffness and crack patterns.