Test-bed site in Honam High Speed Railway is under construction for developing infra system core technology and speed-up test over 400km/h. High Speed Railway Infra System’s development are composed of comprehensive research developments which are comprising infra system such as railraod infrastructure, environmental noise reduction, catenary, train control and etc. For high speed-up, the review of track alignment, structural and running safety are required. In this paper, speed-up patterns of train by TPS and structural safety according to load variation are evaluated.