Taxol(paclitaxel) is used in chemotherapy against several cancer. Treatment of tumor cell lines with taxol induces apoptosis, but exact mechanism is not sufficiently understood. The purpose of this study was to investigate apoptosis by the inhibitory effect of paclitaxel on the motility properties of human salivary gland adenocarcinoma cell lines. Paclitaxel inhibited cell motility induced by soluble and immobilized attractant. It suggested that paclitaxel would be a potent inhibitor of salivary gland adenocarcinoma cell motility independent of its cytotoxic and apoptotic activity.

I. Introduction
 II. Materials and Methods
  1. Drug Preparation and Cell Culture
  2. MTT Assay
  3. Motility Assays
 III. Results
 IV. Discussions
 V. References

• 이종헌(Department of Oral and Maxillofacial Pathology, Dental College, Dankook University) | Chong Heon Lee correspondence