In order to develop a protective carrier scaffolder for the external usage of medical and hygienic materials, three essential protective elements existing in nature, i.e., algin, cellulose, and calcium phosphate apatite, were investigated. The algin is a main skeletal component of sea weeds, the cellulose is of vegetables, and the calcium phosphate apatite is of vertebral animals. In the present study we select the agarose which is a derivative from algin, the cellulose fiber obtained from skin of sea squirt, calcium oxide purified from shell powder, and tricalcium phosphate apatite purchased commercially. Consequently, the agarose-cellulose hybrid was made by the hydrogen bonds intermediating the calcium phosphate apatite between agarose and cellulose molecules. As the calcium phosphate apatite is formed by the addition of calcium hydroxide into tricalcium phosphate solution, we used calcium oxide to accelerate the hybridization between the agarose and calcium phosphate apatite and also between the cellulose and calcium phosphate apatite. In the phase contrast microscopic observation the agarose-cellulose hybrid showed more compact matrix structure than the mixture of agarose and cellulose. The agarose-cellulose hybrid showed increased storage modulus but decreased loss modulus in Rheometer test compared to those of the other materials tested in this study, representing that the agarose-cellulose hybrid has the highest elasticity among them and similar water capacity to agarose. The agarose-cellulose hybrid showed the strongest antimicrobial effect in bacteria killing assay than the other materials, and also it showed a potent blood clotting effect but no immunological hypersensitivity on the human skin. From the above results we presumed that the nobel material, agarose-cellulose hybrid, is a compact scaffolding matrix which has proper elasticity, high capacity to hold substrates, and antimicrobial and blood clotting property potent enough to carry the bio-medical and hygienic materials for external treatment safely.

I. 서론
 II. 실험재료 및 방법
  1. 아가로즈-셀룰로오스 하이브리드의 제작
  2. 아가로즈-셀룰로오스 하이브리드의 물리화학적성질
 III. 연구결과
  1. 아가로즈-셀룰로오스 하이브리드의 제조
  2. 아가로즈-셀룰로오스 하이브리드의 물리화학적성질
 IV. 총괄 및 고안
 V. 결론
 VI. 참고문헌

• 임재길(강릉대학교 생명과학대학 식품공학교실) | Jae Geel Lim
• 윤정로(강릉대학교 생명과학대학 식품공학교실) | Jung Ro Yoon
• 김성민(서울대학교 치과대학 구강악안면 외과학교실) | Soung Min Kim
• 송지용(치과대학 병리학교실) | Ji Yong Song
• 김연숙(치과대학 병리학교실) | Yeon Sook Kim
• 이석근(치과대학 병리학교실) | Suk Keun Lee correspondence