The purpose of this study is to establish and examine the analytical methods based on FEA to predict the behavior of the precast prestressed concrete panels under blast loading. The precast prestressed concrete structures are on the rise, but there is little research in this regard explosion. In this paper, we set the variable to the three models. TNT 500 kg was an explosion in the standoff-distance 3m. In conclusion, the precast models damage was concentrated in the bonded portion. The concrete panels after an explosion occurred continuously deformed. But the including prestressed panels deformation occurs only at the beginning of the explosion were able to see the results.