Primary localized amyloidosis of the palate is a rare condition. We present a case of localized amyloidosis of the palate of a 49-year-old Korean female who suffered from asymptomatic nodular swelling. Microscopic examination revealed extensive deposition of pale eosinophilic amorphous material throught the lamina propria and within the walls of small blood vessels. A diagnosis of localized amyloidosis was made after the biopsy revealed characteristic staining on Congo red, and an extensive workup for systemic involvement was negative. Localized amyloidosis should be considered in the differential diagnosis of palatal nodular lesions