A 41-year-old male patient complained of a whitish growing mass on the central area of palate. The exophytic keratinizing mass was recently grown and showed rough surface localized at palatal mucosa. He has heavily smoked for more than 25 years. The lesion was clearly demarcated as an out-growing verrucous whitish epithelial lesion with erosive mucosa in the periphery and also continuous with the extensive hyperkeratosis in whole hard palatal mucosa. In the histological examination there appeared a plaque type verrucous hyperplasia in the absence of papillomatous growth. In the series of immunostains including PCNA, p53, β-catenin, APC, E-cadherin, BCL-2, MMP-1 and MMP-3 showed no features of infiltrative growth and malignant transformation. Therefore, the present case was diagnosed oral verrucous hyperplasia(OVH) different from squamous cell papilloma, verrucous leukoplakia, verrucous carcinoma, and oral squamous cell carcinoma.

Ⅰ. INTRODUCTION
 Ⅱ. CASE REPORT
 Ⅲ. DISCUSSION
 Ⅳ. REFERENCES

• 김연숙(Cheongju University Department of Dental Hygiene) | Yeon Sook Kim
• 양재희(College of Dentistry, Gangneung-Wonju National University Department of Oral Pathology) | Jae Hee Yang
• 이석근(College of Dentistry, Gangneung-Wonju National University Department of Oral Pathology) | Suk Keun Lee correspondence