Chronic hyperplastic candidiasis (CHC) is characterized by epithelial hyperplasia of the oral mucosa associated with candidal hyphae. The immune status of host is one of the factors that induce clinically evident candidal infection. Host defense mechanisms include inflammatory cells, epithelial barrier, and antimicrobial peptides such as human beta 2 defensin (hBD-2). In the present study, we investigated the densities of CD4+/CD8+ T lymphocytes and hBD-2 expression of epithelial cells in CHC. Immunohistochemical staining was performed on 10 cases of CHC using CD4, CD8 and hBD-2. Ten specimens of chronic mucositis were selected for comparison, and went through the same examination. hBD-2 was expressed in the spinous cell layers and the keratin layers of 7 CHC patients, while the epithelium of chronic mucositis did not demonstrate the hBD-2 expression except for one case. Also, hBD-2 expression was stronger when the hyphae invaded the upper stratum spinosum (P =.019). However, the densities of CD8+ T lymphocytes were significantly lower in the CHC patients, suggesting that the ability of CD8+ T cells to enter the epithelium and target the pathogenic hyphae was decreased in CHC. Increased hBD-2 expression seemed to be significantly associated with the candidal infection, while not promoting the cell-mediated immune reaction in CHC.

Ⅰ. 서론
 Ⅱ. 재료 및 방법
  1. 연구대상
  2. 면역조직화학적 염색
  3. 염색결과의 판독
  4. 통계학적 분석
 III. 결과
  1. 조직병리학적 소견
  2. CHC와 CM에서의 hBD-2의 발현
  3. CHC와 CM에서의 CD4+ 및 CD8+ T 림프구의 분포 양상
  4. 구강 점막 병소에서 hBD-2의 발현과 캔디다 균사의 위치 및 림프구 침윤과의 관계
 Ⅳ. 고찰
 V. 참고문헌

• 윤대웅(서울대학교 치의학대학원 구강병리학교실) | Dae Woong Yoon
• 조영아(서울대학교 치의학대학원 구강병리학교실) | Young Ah Cho
• 김수진(서울대학교 치의학대학원 구강병리학교실) | Soo Jin Kim
• 윤혜정(서울대학교 치의학대학원 구강병리학교실) | Hye Jung Yoon
• 홍성두(서울대학교 치의학대학원 구강병리학교실) | Seong Doo Hong
• 이재일(서울대학교 치의학대학원 구강병리학교실) | Jae Il Lee
• 홍삼표(서울대학교 치의학대학원 구강병리학교실) | Sam Pyo Hong correspondence