Spotted wing drosophila, Drosophila suzukii, native to eastern and southeastern Asia, has become one of the most harmful pests causing serious damage to fruits such as blueberry, cherry, and others in Northern America and Europe. For quarantine sanitary purpose, methyl bromide (MeBr) has been used for a long time. However, it is under regulation because of its adverse effect of ozone layer depletion. Thus, alternative strategies to MeBr are needed to meet the quarantine requirement. In this study, we investigated effects of gamma ray irradiation (0, 50, 100, 200 and 300 Gy) on the development and reproduction of D. suzukii to offer a guideline in using gamma ray for dis-infestation of this pest. The higher doses of gamma ray caused more adverse effects on development and hatchability of D. suzukii. Development and oviposition of D. suzukii was significantly depressed at above certain doses, respective to each developmental stage. When eggs were treated with the doses of gamma ray, eggs hatched in some ratios at all doses. Even though some larvae developed to pupae under 100 Gy irradiation, all these pupae did not emerge to adults at all doses. When larvae were treated with gamma ray, some of them pupated at each doses. However these pupae did not emerge to adults at all under all doses. When pupae were irradiated, the emerged adults did not oviposit eggs above 100 Gy. When adults were irradiated, oviposition occurred normally, but fecundity and hatchability of the eggs were reciprocal to the doses.