Mushroom is known for anti-inflammatory and anti-oxidative potential. This study provides evidence that theinhibitory effect of mushroom on the expression of pro-inflammatory cytokines in human keratinocytes, HaCaT cells. To definethe underlying mechanisms of action, tumor necrosis factorα/IFNγ-activated human keratinocytes model was used. Mushroomsignificantly inhibited the expression of cytokines in HaCaT cells. Taken together, the results demonstrate that mushroom inhibitedinflammtion, suggesting that mushroom (DW extract: Grifola frondosa Cordyceps militaris), (Ethanol extract: Ganoderma lucidum,Lentinus edodes, Cordyceps militaris, Flammulina velutipes) might be a candidate for the treatment of skin inflammation.

서 론
 재료 및 방법
  버섯시료 추출
  세포 배양
  RNA isolation
  역전사 반응(Reverse Transcription-Polymerase ChainReaction, RT-PCR)
  PCR정량 분석
  통계처리
 결과 및 고찰
  피부각질세포(HaCaT)에서의 TNF-a/INF-g처리에 의한열수 추출물의 TNF-a mRNA 발현 억제효과
  피부각질세포(HaCaT)에서의 TNF-a/INF-g처리에 의한에탄올 추출물의 TNF-a mRNA 발현 억제효과
 적 요
 감사의 글
 Reference

• 최은주(건국대학교 과학기술대학 스포츠과학부) | Eun-Ju Choi
• 김은경(건국대학교 의료생명대학 식품생명과학부) | Eun-Kyung Kim
• 지용석(청주대학교 체육교육학과) | Yong-Seok Ji
• 이창진(건국대학교 과학기술대학 스포츠과학부) | Chang-Jin Lee Corresponding author