Background : The white jelly mushroom (Tremella fuciformis), one of the most popular edible fungi, has medicinal properties. However, the effects of T. fuciformis in skin whitening or anti-wrinkle efficacy has not been defined to date. The aim of the present study was to investigate the effects of T. fuciformis extracts on whitening and anti-wrinkle efficacy in skin cells. Methods and Results :We prepared T. fuciformis extracts with water. The extracts (80℃) contained 12.11 ㎎/g polyphenol and 8.54 ㎎/g flavonoid concentration. T. fuciformis extracts markedly decreased melanin contents and tyrosinase activity in α-MSHstimulated melanocytes (B16F10 cells). In addition, the mRNA expression of melanin formation factors, such as microphthalmiaassociated transcription factor (MITF), tyrosinase-related protein-1 (TRP-1) and tyrosinase-related protein-2 (TRP-2) were significantly down-regulated in α-MSH-stimulated melanocyte. Furthermore, T. fuciformis extracts increased the synthesis of type I procollagen and reduced mRNA expression of matrix metalloproteinase 1 (MMP-1) in the human dermal fibroblast (HDFn cells). These data indicated that T. fuciformis extracts induce repression of cellular melanogenesis and protect against wrinkles caused by UVB-stimulated damage. Conclusions : Thus T. fuciformis extracts could be a cosmetic candidate for skin whitening and anti-wrinkle effects.

• 이광호((주)하원제약) | Kwang Ho Lee
• 박현수((주)하원제약) | Hyun Soo Park
• 윤일주((주)하원제약) | Il Joo Yoon
• 신용봉((주)하원제약) | Young Bong Shin
• 백영찬((주)하원제약) | Young Chan Baik
• 구대호((주)하원제약) | Dae Ho Kooh
• 김성규((주)하원제약) | Sung Kew Kim
• 정호경(전남한방산업진흥원) | Ho Kyung Jung
• 심미옥(전남한방산업진흥원) | Mi Ok Sim
• 조현우(전남한방산업진흥원) | Hyun Woo Cho
• 정원석(전남한방산업진흥원) | Won Seok Jung
• 김명석((주)하원제약) | Myoung Seok Kim Corresponding author