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치관, 치근 상아질에서 우식의 진행에 따른 Matrix Metalloproteinase- 8과 13의 서로 다른 발현 양상에 관한 연구 KCI 등재

Differential Expressions of Matrix Metalloproteinase- 8 and 13 in Human Coronal and Radicular Dentin with Progression of Caries

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대한구강악안면병리학회지 (The Korean Journal of Oral and Maxillofacial Pathology)
대한구강악안면병리학회 (Korean Academy Of Oral And Maxillofacial Pathology)
초록

Background: Matrix metalloproteinases (MMPs) are proteolytic enzymes involved in degradation of the extracellular matrix. MMP-8 has been reported to be involved in the degradation of collagen in progression of dental caries. MMP-13 was found to be expressed in both normal and caries pulp, implying its involvement in the pathogenesis of dental caries. Methods: Four extracted teeth were used. They were categorized into four grades according to caries progression. Three sections were prepared from each separated crown and root. Immunofluorescence of the FITC of the MMP-8 and 13 in coronal and radicular dentin was analyzed by confocal microscopy. Results: Immunofluorescence signals that were indicative of MMP-8 were observed both in radicular and coronal dentin in the sound, C1 and C3 carious teeth. In C2 carious teeth, immunofluorescence signals that were indicative of MMP-8 were observed only in radicular dentin. Immunofluorescence signals that were indicative of MMP-13 were observed both in radicular and coronal dentin in the sound teeth. In C1, C2 and C3 carious teeth, immunofluorescence signals that were indicative of MMP-13 were not observed both in radicular and coronal dentin. Conclusion: Immunofluorescence signals revealed that MMP-8 and 13 were present in coronal and radicular dentin, and was differently expressed as caries progressed.

목차
Ⅰ. INTRODUCTION
 Ⅱ. MATERIALS AND METHODS
  1. Preparation of teeth
  2. Specimen preparation
  3. MMP-13 immunofluorescence
 Ⅲ. RESULTS
 Ⅳ. DISCUSSION
 Ⅴ. REFERENCES
저자
  • 이태연(가톨릭 대학교 여의도 성모병원 치과 보존과) | Tae Yeon Lee Correspondence