Invasive fungal infection can be a lethal complication in systemic lupus erythematosus (SLE). Crytococcus neoformans, as one of the most common pathogenic species worldwide, can cause infection disease in human. The central nervous system (CNS) is a common site for cryptococcal infection which usually presents cryptococcal meningitis. The cryptococcal meningitis is a recognized complication of SLE, with high mortality rates, particularly in those treated with immunosuppressive agents. However, it is difficult to differentiate infectious meningitis and neuropsychiatric lupus because of the clinical manifestations are unspecific and frequently are confused with lupus activity. So a early diagnosis and treatment is very important for its significant mortality and morbidity. We report the case of fatal meningoencephalitis by Cryptococcus neoforman in a 44 years old patient with SLE

• 김영숙(조선대학교 의학전문대학원 영상의학교실) | Young Sook Kim
• 문도식(조선대학교 의학전문대학원 내과학교실) | Do Sik Moon
• 김윤성(조선대학교 의학전문대학원 내과학교실) | Yun Sung Kim Corresponding author